Anti-Human JAM3 Recombinant Antibody (SAA1837) (HP669013)

Name: Anti-Human JAM3 Recombinant Antibody (SAA1837)
Brand: abinScience
SKU: HP669013
Price: 196 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HP669013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1837

Clonality

Monoclonal

Target

JAM-3, JAM-C, JAM-2, Junctional adhesion molecule 3, Junctional adhesion molecule C, sJAM-C, JAM3

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9BX67

RRID

Anti-Human JAM3 Antibody (SAA1837) (abinScience Cat# HP669013, RRID:AB_3727600)
_x005F_x005F_x000D_

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Junctional adhesion molecule C (JAM3) is a ~35 kDa protein. Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium. Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation.

1. Arrate, MP. et al. (2001) The Journal of biological chemistry 276, 45826-32. PMID: 11590146

2. Liang, TW. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 1618-26. PMID: 11823489

3. Arcangeli, ML. et al. (2014) Stem cells (Dayton, Ohio) 32, 1043-54. PMID: 24357068

4. Santoso, S. et al. (2002) The Journal of experimental medicine 196, 679-91. PMID: 12208882

5. Zen, K. et al. (2004) Molecular biology of the cell 15, 3926-37. PMID: 15194813

6. Akawi, NA. et al. (2013) Human mutation 34, 498-505. PMID: 23255084

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human JAM3 Antibody (SAA1837)

References

Datasheet

Anti-Human JAM3 Recombinant Antibody (SAA1837).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human JAM3 Recombinant Antibody (SAA1837) (HP669013)

Overview

Images

References

Datasheet

SDS

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