Anti-Human KANK2 Polyclonal Antibody (HA852014)

Name: Anti-Human KANK2 Polyclonal Antibody
Brand: abinScience
SKU: HA852014
Price: 96 USD
Availability: InStock

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References
Datasheet
SDS

Overview

Catalog No.

HA852014

Description

Anti-Human KANK2 Polyclonal Antibody (HA852014) is a rabbit polyclonal antibody detecting KANK2 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human KANK2 (Met1-Asn161).

Target

Ankyrin repeat domain-containing protein 25, SRC-interacting protein, SRC-1-interacting protein, SRC1-interacting protein, ANKRD25, KIAA1518, MXRA3, KN motif and ankyrin repeat domain-containing protein 2, Matrix-remodeling-associated protein 3, KANK2, SIP

Purification

Purified by antigen affinity column.

Accession

Q63ZY3

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

KN motif and ankyrin repeat domain-containing protein 2 (KANK2) is a ~91 kDa protein. Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3. Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria. Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis. Involved in the negative control of vitamin D receptor signaling pathway. Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway.

1. Zhang, Y. et al. (2007) The EMBO journal 26, 2645-57. PMID: 17476305

2. Wang, D. et al. (2012) The Journal of biological chemistry 287, 12612-21. PMID: 22371500

3. Ramot, Y. et al. (2014) Journal of medical genetics 51, 388-94. PMID: 24671081

4. Zhu, Y. et al. (2008) Biochimica et biophysica acta 1780, 128-33. PMID: 17996375

5. Gee, HY. et al. (2015) The Journal of clinical investigation 125, 2375-84. PMID: 25961457

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-CDC5L polyclonal antibody at 1ug/mL on various samples.
Lane 1: HepG2 cell lysate
Lane 2: Jurkat cell lysate
Lane 3: Mouse testis lysate
Lane 4: Rat testis lysate

References

Datasheet

Anti-Human KANK2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human KANK2 Polyclonal Antibody (HA852014)

Overview

Images

References

Datasheet

SDS

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