Anti-Human KCNH1/EAG1 Recombinant Antibody (SAA1808) (HF003013)

Name: Anti-Human KCNH1/EAG1 Recombinant Antibody (SAA1808)
Brand: abinScience
SKU: HF003013
Price: 196 USD
Availability: InStock

Datasheet Share product Copy info

Price(USD):

Spec:

50ug
100ug
1mg

Number:

Get quote

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HF003013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1808

Clonality

Monoclonal

Target

EAG channel 1, KCNH1, Voltage-gated potassium channel subunit Kv10.1, h-eag, hEAG1, Ether-a-go-go potassium channel 1, EAG, EAG1, Potassium voltage-gated channel subfamily H member 1

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O95259

RRID

Anti-Human KCNH1/EAG1 Antibody (SAA1808) (abinScience Cat# HF003013, RRID:AB_3727570)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Voltage-gated delayed rectifier potassium channel KCNH1 (EAG1) is a ~111 kDa protein. Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate. The activation kinetics depend on the prepulse potential and external divalent cation concentration. With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation. The time course of activation is biphasic with a fast and a slowly activating current component. Activates at more positive membrane potentials and exhibit a steeper activation curve.

1. Schönherr, R. et al. (2000) The EMBO journal 19, 3263-71. PMID: 10880439

2. Schönherr, R. et al. (2002) FEBS letters 514, 204-8. PMID: 11943152

3. Marques-Carvalho, MJ. et al. (2012) Journal of molecular biology 423, 34-46. PMID: 22732247

4. Simons, C. et al. (2015) Nature genetics 47, 73-7. PMID: 25420144

5. Mortensen, LS. et al. (2015) The Journal of physiology 593, 181-96. PMID: 25556795

6. Kortüm, F. et al. (2015) Nature genetics 47, 661-7. PMID: 25915598

7. Han, B. et al. (2016) Scientific reports 6, 23417. PMID: 27005320

8. Lörinczi, E. et al. (2016) The Journal of biological chemistry 291, 17907-18. PMID: 27325704

9. Marques-Carvalho, MJ. et al. (2016) Structure (London, England : 1993) 24, 1742-1754. PMID: 27618660

10. Ma, L. et al. (2018) Biochemical pharmacology 158, 60-72. PMID: 30149017

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human KCNH1/EAG1 Antibody (SAA1808)

References

Datasheet

Anti-Human KCNH1/EAG1 Recombinant Antibody (SAA1808).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human KCNH1/EAG1 Recombinant Antibody (SAA1808) (HF003013)

Overview

Images

References

Datasheet

SDS

Quick access

Contact Us