Anti-Human KCNK3 Polyclonal Antibody (HT022014)

Name: Anti-Human KCNK3 Polyclonal Antibody
Brand: abinScience
SKU: HT022014
Price: 168 USD
Availability: InStock

Datasheet Share product Copy info

Price(USD):

Spec:

50ug
100ug

Number:

Get quote

Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HT022014

Description

Anti-Human KCNK3 Polyclonal Antibody (HT022014) is a rabbit polyclonal antibody detecting KCNK3. Suitable for Human.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human KCNK3 (Leu244-Val394).

Target

Acid-sensitive potassium channel protein TASK-1, KCNK3, Potassium channel subfamily K member 3, TASK, TASK1, TWIK-related acid-sensitive K(+) channel 1, Two pore K(+) channel KT3.1, Two pore potassium channel KT3.1

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

O14649

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

Potassium channel subfamily K member 3 (KCNK3) is a ~43 kDa protein. K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Changes ion selectivity and becomes permeable to Na(+) ions in response to extracellular acidification. Protonation of the pH sensor His-98 stabilizes C-type inactivation conformation likely converting the channel from outward K(+)-conducting, to inward Na(+)-conducting to nonconductive state. Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties.

1. Plant, LD. et al. (2012) Science signaling 5, ra84. PMID: 23169818

2. Schewe, M. et al. (2016) Cell 164, 937-49. PMID: 26919430

3. Rödström, KEJ. et al. (2020) Nature 582, 443-447. PMID: 32499642

4. Sörmann, J. et al. (2022) Nature genetics 54, 1534-1543. PMID: 36195757

5. Duprat, F. et al. (1997) The EMBO journal 16, 5464-71. PMID: 9312005

6. Ma, L. et al. (2012) The Journal of biological chemistry 287, 37145-53. PMID: 22948150

Note

For research use only

Images

References

Datasheet

Anti-Human KCNK3 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human KCNK3 Polyclonal Antibody (HT022014)

Overview

Images

References

Datasheet

SDS

Quick access

Contact Us