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Anti-Human KIDINS220 Polyclonal Antibody (HD508014)

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Overview
Catalog No.HD508014
Description
Anti-Human KIDINS220 Polyclonal Antibody (HD508014) is a rabbit polyclonal antibody detecting KIDINS220. Suitable for Rat and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human KIDINS220 (Met1-Lys168).
Target ARMS, Ankyrin repeat-rich membrane-spanning protein, KIAA1250, KIDINS220, Kinase D-interacting substrate of 220 kDa
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q9ULH0
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Kinase D-interacting substrate of 220 kDa (KIDINS220) is a ~196 kDa protein. Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.

Note For research use only
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Formula
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Anti-Human KIDINS220 Polyclonal Antibody

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