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Anti-Human KPTN Polyclonal Antibody (HD506014)

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Overview
Catalog No.HD506014
Description
Anti-Human KPTN Polyclonal Antibody (HD506014) is a rabbit polyclonal antibody detecting KPTN. Suitable for Human.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human KPTN (Met1-Ser396).
Target Actin-associated protein 2E4, KICSTOR complex protein kaptin, KPTN
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q9Y664
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

KICSTOR complex protein kaptin (KPTN) is a ~48 kDa protein. As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.

Note For research use only
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Formula
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Anti-Human KPTN Polyclonal Antibody

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