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Anti-Human L3MBTL1 IP Recombinant Antibody (SAA0263) (HP549013)

Anti-Human L3MBTL1 IP Recombinant Antibody (SAA0263)
Anti-Human L3MBTL1 IP Recombinant Antibody (SAA0263)
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Overview
Catalog No.HP549013
Species reactivityHuman
ApplicationsELISA, IF, IP
Host speciesMouse
IsotypeIgG1
Clone IDSAA0263
Clonality Monoclonal
Target L(3)mbt-like, H-l(3)mbt protein, H-l(3)mbt, Lethal(3)malignant brain tumor-like protein 1, L3MBT, L3MBTL1, KIAA0681, L3MBTL, L(3)mbt protein homolog
Endotoxin level Please contact with the lab for this information.
Purity >95% as determined by SDS-PAGE.
Purification Protein A/G purified from cell culture supernatant.
Accession Q9Y468
RRID Anti-Human L3MBTL1 IP Antibody (SAA0263) (abinScience Cat# HP549013, RRID:AB_3729797)
Form Liquid
Storage buffer 0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information
Application Dilution
ELISA 1:2000-1:20000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background

Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1) is a ~92 kDa protein. Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, thereby acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53-target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys-860'. Participates in the ETV6-mediated repression.

Note For research use only.
Images
  • Anti-Human L3MBTL1 IP Recombinant Antibody (SAA0263)

    SDS-PAGE

    SDS-PAGE for Anti-Human L3MBTL1 IP Antibody (SAA0263)

References
Formula
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