Anti-Human L3MBTL3 IP Recombinant Antibody (SAA0209) (HP399013)

Name: Anti-Human L3MBTL3 IP Recombinant Antibody (SAA0209)
Brand: abinScience
SKU: HP399013
Price: 191 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HP399013

Species reactivity

Human

Applications

ELISA, IF, IP, IP-MS

Host species

Mouse

Isotype

IgG1

Clone ID

SAA0209

Clonality

Monoclonal

Target

Lethal(3)malignant brain tumor-like protein 3, H-l(3)mbt-like protein 3, KIAA1798, L3MBTL3, L3mbt-like 3, MBT-1, L(3)mbt-like protein 3, MBT1

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q96JM7

RRID

Anti-Human L3MBTL3 IP Antibody (SAA0209) (abinScience Cat# HP399013, RRID:AB_3729743)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Lethal(3)malignant brain tumor-like protein 3 (L3MBTL3) is a ~88 kDa protein. Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression. It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation. Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins. Required for normal maturation of myeloid progenitor cells.

1. Xu, T. et al. (2017) The EMBO journal 36, 3232-3249. PMID: 29030483

2. Leng, F. et al. (2018) Nature communications 9, 1641. PMID: 29691401

3. Zhang, C. et al. (2019) The Journal of biological chemistry 294, 476-489. PMID: 30442713

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human L3MBTL3 IP Antibody (SAA0209)

References

Datasheet

Anti-Human L3MBTL3 IP Recombinant Antibody (SAA0209).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human L3MBTL3 IP Recombinant Antibody (SAA0209) (HP399013)

Overview

Images

References

Datasheet

SDS

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