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Anti-Human LARP7 Polyclonal Antibody (HS837014)

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Overview
Catalog No.HS837014
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human LARP7 (Met1-Asn187).
Target La ribonucleoprotein domain family member 7, La-related protein 7, hLARP7, P-TEFb-interaction protein for 7SK stability, LARP7, PIP7S
Purification Purified by antigen affinity column.
Accession Q4G0J3
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

La-related protein 7 (LARP7) is a ~66 kDa protein. RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function. Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II. The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex.

1. He, N. et al. (2008) Molecular cell 29, 588-99. PMID: 18249148
2. Hasler, D. et al. (2020) Molecular cell 77, 1014-1031.e13. PMID: 32017898
3. Markert, A. et al. (2008) EMBO reports 9, 569-75. PMID: 18483487
4. Egloff, S. et al. (2017) The EMBO journal 36, 934-948. PMID: 28254838
5. Krueger, BJ. et al. (2008) Nucleic acids research 36, 2219-29. PMID: 18281698
Note For research use only.
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Anti-Human LARP7 Polyclonal Antibody

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