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Anti-Human LIN28B Polyclonal Antibody (HC186014)

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Overview
Catalog No.HC186014
Description
Anti-Human LIN28B Polyclonal Antibody (HC186014) is a rabbit polyclonal antibody detecting LIN28B. Suitable for Mouse and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human LIN28B (Gln26-Gly101).
Target CSDD2, LIN28B, Lin-28B, Protein lin-28 homolog B
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q6ZN17
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Protein lin-28 homolog B (LIN28B) is a ~27 kDa protein. Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA. Does not act on pri-miR21. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation.

1. Piskounova, E. et al. (2011) Cell 147, 1066-79. PMID: 22118463
2. Heo, I. et al. (2009) Cell 138, 696-708. PMID: 19703396
Note For research use only
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Formula
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Anti-Human LIN28B Polyclonal Antibody

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