Anti-Human LMNB1 Polyclonal Antibody (HB096024)

Name: Anti-Human LMNB1 Polyclonal Antibody
Brand: abinScience
SKU: HB096024
Price: 96 USD
Availability: InStock

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HB096024

Description

Anti-Human LMNB1 Polyclonal Antibody (HB096024) is a rabbit polyclonal antibody detecting LMNB1 in ELISA, IHC, WB. Suitable for Human, Mus musculus, Rattus norvegicus, and Gallus gallus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human LMNB1 (Ala426-Glu558).

Target

LMNB1

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P20700

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternate Names

Lamin-B1, LMNB1, LMN2, LMNB

Background

Lamin-B1 (LMNB1) is a ~66 kDa protein. Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively.

1. Pedroso, JL. et al. (2017) Journal of the neurological sciences 379, 249-252. PMID: 28716252

2. Cristofoli, F. et al. (2020) American journal of human genetics 107, 753-762. PMID: 32910914

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-LMNB1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Hela cell lysate
Lane 2: K562 cell lysate
Lane 3: HepG2 cell lysate
Lane 4: NIH3T3 cell lysate
Lane 5: Mouse spleen lysate
Lane 6: Rat spleen lysate
Lane 7: Rat testis lysate