Anti-Human Lp-PLA2/PLA2G7/PAF-AH Recombinant Antibody (SAA1765) (HC293013)

Name: Anti-Human Lp-PLA2/PLA2G7/PAF-AH Recombinant Antibody (SAA1765)
Brand: abinScience
SKU: HC293013
Price: 196 USD
Availability: InStock

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100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HC293013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1765

Clonality

Monoclonal

Target

Platelet-activating factor acetylhydrolase, PAFAH, PAF 2-acylhydrolase, PAF acetylhydrolase, 2-acetyl-1-alkylglycerophosphocholine esterase, 1-alkyl-2-acetylglycerophosphocholine esterase, LDL-PLA(2), LDL-associated phospholipase A2, PLA2G7, Group-VIIA phospholipase A2, gVIIA-PLA2

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q13093

RRID

Anti-Human Lp-PLA2/PLA2G7/PAF-AH Antibody (SAA1765) (abinScience Cat# HC293013, RRID:AB_3727526)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Platelet-activating factor acetylhydrolase (Lp-PLA2/PLA2G7) is a ~50 kDa protein. Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response. At the lipid-aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position. Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups. Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent pro-inflammatory signaling lipid that acts through PTAFR on various innate immune cells.

1. Stafforini, DM. et al. (1999) The Journal of biological chemistry 274, 7018-24. PMID: 10066756

2. Stafforini, DM. et al. (2006) The Journal of biological chemistry 281, 4616-23. PMID: 16371369

3. Kriska, T. et al. (2007) The Journal of biological chemistry 282, 100-8. PMID: 17090529

4. Stremler, KE. et al. (1991) The Journal of biological chemistry 266, 11095-103. PMID: 2040620

5. Tjoelker, LW. et al. (1995) Nature 374, 549-53. PMID: 7700381

6. Tew, DG. et al. (1996) Arteriosclerosis, thrombosis, and vascular biology 16, 591-9. PMID: 8624782

7. Min, JH. et al. (1999) Biochemistry 38, 12935-42. PMID: 10504265

9. Gardner, AA. et al. (2008) The Journal of biological chemistry 283, 17099-106. PMID: 18434304

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human Lp-PLA2/PLA2G7/PAF-AH Antibody (SAA1765)

References

Datasheet

Anti-Human Lp-PLA2/PLA2G7/PAF-AH Recombinant Antibody (SAA1765).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human Lp-PLA2/PLA2G7/PAF-AH Recombinant Antibody (SAA1765) (HC293013)

Overview

Images

References

Datasheet

SDS

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