

| Catalog No. | HW426014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human MAP1B Polyclonal Antibody (HW426014) is a rabbit polyclonal antibody detecting MAP1B in ELISA, IHC, WB. Suitable for Rattus norvegicus, Mus musculus, and Human.
Highlights
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| Species reactivity | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Clonality | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogen | E. coli - derived recombinant Human MAP1B (Lys414-Glu567). | ||||||||
| Target | MAP1B | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | P46821 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Alternate Names | Microtubule-associated protein 1B, MAP-1B, MAP1B heavy chain, MAP1 light chain LC1, MAP1B | ||||||||
| Background | Microtubule-associated protein 1B (MAP1B) is a ~270 kDa protein. Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. 1. Cui, L. et al. (2020) JCI insight 5. PMID: 33268592 | ||||||||
| Note | For research use only. |

Western blot analysis was performed using anti-MAP1B polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse brain lysate
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