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Anti-Human MBLAC1 Polyclonal Antibody (HD132014)

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Overview
Catalog No.HD132014
Description
Anti-Human MBLAC1 Polyclonal Antibody (HD132014) is a rabbit polyclonal antibody detecting MBLAC1. Suitable for Human.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human MBLAC1 (Arg2-Arg236).
Target EC:3.1.27.-, Endoribonuclease MBLAC1, MBLAC1, Metallo-beta-lactamase domain-containing protein 1
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession A4D2B0
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Metallo-beta-lactamase domain-containing protein 1 (MBLAC1) is a ~27 kDa protein. Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase. Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop. May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage.

1. Pettinati, I. et al. (2018) eLife 7. PMID: 30507380
Note For research use only
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Formula
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Anti-Human MBLAC1 Polyclonal Antibody

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