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Anti-Human MBP Polyclonal Antibody (HF789014)

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Overview
Catalog No.HF789014
Description
Anti-Human MBP Polyclonal Antibody (HF789014) is a rabbit polyclonal antibody detecting MBP. Suitable for Human and Rat.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human MBP (Met1-Lys192).
Target MBP, Myelin A1 protein, Myelin basic protein, Myelin membrane encephalitogenic protein
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession P02686
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Myelin basic protein (MBP) is a ~33 kDa protein. The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function.

Note For research use only
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Formula
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Anti-Human MBP Polyclonal Antibody

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