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Anti-Human MECR Polyclonal Antibody (HP611014)

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Overview
Catalog No.HP611014
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human MECR (Arg42-Met373).
Target MECR, NRBF-1, Nuclear receptor-binding factor 1, NBRF1, 2-enoyl thioester reductase, HsNrbf-1, Enoyl-[acyl-carrier-protein] reductase, mitochondrial
Purification Purified by antigen affinity column.
Accession Q9BV79
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Enoyl-[acyl-carrier-protein] reductase, mitochondrial (MECR) is a ~40 kDa protein. Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Displays a preference for medium-chain over short- and long-chain substrates. May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity particularly in Purkinje cells. Involved in iron homeostasis; affecting Fe-S cluster assembly and ceramide metabolism.

1. Miinalainen, IJ. et al. (2003) The Journal of biological chemistry 278, 20154-61. PMID: 12654921
2. Chen, ZJ. et al. (2008) Journal of molecular biology 379, 830-44. PMID: 18479707
3. Heimer, G. et al. (2016) American journal of human genetics 99, 1229-1244. PMID: 27817865
4. Dutta, D. et al. (2023) Nature metabolism 5, 1595-1614. PMID: 37653044
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-Human MECR Polyclonal Antibody

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