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Anti-Human MGRN1 Polyclonal Antibody (HT060014)

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Overview
Catalog No.HT060014
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human MGRN1 (Asp16-Gln251).
Target KIAA0544, RING finger protein 156, RNF156, Mahogunin RING finger protein 1, E3 ubiquitin-protein ligase MGRN1, MGRN1, RING-type E3 ubiquitin transferase MGRN1
Purification Purified by antigen affinity column.
Accession O60291
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

E3 ubiquitin-protein ligase MGRN1 is a ~60 kDa protein. E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling.

1. Kim, BY. et al. (2007) Molecular biology of the cell 18, 1129-42. PMID: 17229889
2. Jiao, J. et al. (2009) Biochimica et biophysica acta 1792, 1027-35. PMID: 19703557
3. Pérez-Oliva, AB. et al. (2009) The Journal of biological chemistry 284, 31714-25. PMID: 19737927
Note For research use only.
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Formula
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Anti-Human MGRN1 Polyclonal Antibody

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