Anti-Human/Mouse CD191/CCR1 Recombinant Antibody (SAA2407) (HB896023)

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Overview

Catalog No.

HB896023

Description

Anti-Human/Mouse CD191/CCR1 Antibody (SAA2407) [SAA2407] (HB896023) is a mouse monoclonal antibody detecting CD191 in ELISA, FCM, Neutralization. Suitable for Human and Mouse.

Highlights

●Multi-Application — Validated across multiple applications.
●Flow Cytometry — Validated for flow cytometry applications.

Species reactivity

Human, Mouse

Applications

ELISA, FCM, Neutralization

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA2407

Clonality

Monoclonal

Target

C-C chemokine receptor type 1, C-C CKR-1, CC-CKR-1, CCR-1, CCR1, HM145, LD78 receptor, Macrophage inflammatory protein 1-alpha receptor, MIP-1alpha-R, RANTES-R, CD191, CCR1, CMKBR1, CMKR1, SCYAR1

Endotoxin level

<10 EU/mg

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P32246, P51675

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Background

C-C chemokine receptor type 1 (CD191/CCR1) is a ~41 kDa protein. Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses. Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine. For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF and leukotriene B4. Also mediates monocyte migration upon CXCL4 binding.

1. Tian, Y. et al. (2004) European journal of immunology 34, 785-795. PMID: 14991608

2. Berahovich, RD. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 174, 7341-51. PMID: 15905581

3. Wei, H. et al. (2024) Cellular signalling 117, 111122. PMID: 38417634

4. Fox, JM. et al. (2018) Scientific reports 8, 9466. PMID: 29930254

Note

For research use only

Images

SDS-PAGE

SDS-PAGE for Anti-Human/Mouse CD191/CCR1 Antibody (SAA2407)

References

Datasheet

Anti-Human/Mouse CD191/CCR1 Recombinant Antibody (SAA2407).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human/Mouse CD191/CCR1 Recombinant Antibody (SAA2407) (HB896023)

Overview

Images

References

Datasheet

SDS

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