Anti-Human NMES1 Recombinant Antibody (SAA1899) (HA194013)

Name: Anti-Human NMES1 Recombinant Antibody (SAA1899)
Brand: abinScience
SKU: HA194013
Price: 196 USD
Availability: InStock

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100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HA194013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1899

Clonality

Monoclonal

Target

Protein FOAP-11, C15orf48, NMES1, Normal mucosa of esophagus-specific gene 1 protein

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9C002

RRID

Anti-Human NMES1 Antibody (SAA1899) (abinScience Cat# HA194013, RRID:AB_3727663)
_x005F_x000D_

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Cytochrome c oxidase associated subunit FA4L3 (NMES1) is a ~9 kDa protein. Mitochondrial small peptide that orchestrates a two-pronged immunoregulatory mechanism in response to inflammatory stimuli. Replaces the canonical cytochrome c oxidase subunit COXFA4 in mitochondrial complex IV and targets it to degradation, attenuating mitochondrial respiration, reducing membrane potential as well as ROS generation and modulates innate immune signaling. Additionally, initiates stress-independent autophagy by lowering ATP levels, activating AMPK-ULK1 signaling, boosting glutathione production, and thereby mitigating oxidative stress and supporting immune tolerance.

1. Lee, CQE. et al. (2021) Nature communications 12, 2130. PMID: 33837217

2. Clayton, SA. et al. (2021) Science advances 7, eabl5182. PMID: 34878835

3. Takakura, Y. et al. (2024) Nature communications 15, 953. PMID: 38296961

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human NMES1 Antibody (SAA1899)

References

Datasheet

Anti-Human NMES1 Recombinant Antibody (SAA1899).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human NMES1 Recombinant Antibody (SAA1899) (HA194013)

Overview

Images

References

Datasheet

SDS

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