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Anti-Human NPC1L1 Polyclonal Antibody (HP159014)

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Overview
Catalog No.HP159014
Description
Anti-Human NPC1L1 Polyclonal Antibody (HP159014) is a rabbit polyclonal antibody detecting NPC1L1 in ELISA, IHC, WB. Suitable for Rattus norvegicus and Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human NPC1L1 (Arg450-Ser620).
Target NPC1L1
Purification Purified by antigen affinity column.
Accession Q9UHC9
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate NamesNPC1-like intracellular cholesterol transporter 1, NPC1L1, Niemann-Pick C1-like protein 1, NPC1L1
Background

NPC1-like intracellular cholesterol transporter 1 (NPC1L1) is a ~148 kDa protein. Plays a major role in cholesterol homeostasis. Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption and is approved for the treatment of hypercholesterolemia. May have a function in the transport of multiple lipids and their homeostasis, thereby influencing lipid metabolism regulation.

1. Yamanashi, Y. et al. (2012) Hepatology (Baltimore, Md.) 55, 953-64. PMID: 22095670
2. Garcia-Calvo, M. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 8132-7. PMID: 15928087
3. Davies, JP. et al. (2005) The Journal of biological chemistry 280, 12710-20. PMID: 15671032
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human NPC1L1 Polyclonal Antibody

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