Anti-Human NUPR1 Polyclonal Antibody (HA758014)

Name: Anti-Human NUPR1 Polyclonal Antibody
Brand: abinScience
SKU: HA758014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HA758014

Description

Anti-Human NUPR1 Polyclonal Antibody (HA758014) is a rabbit polyclonal antibody detecting Nuclear protein 1; Candidate of metastasis 1; Protein p8; NUPR1; COM1 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant human NUPR1 (Ala2-Arg82).

Target

Nuclear protein 1; Candidate of metastasis 1; Protein p8; NUPR1; COM1

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

O60356

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Nuclear protein 1 (NUPR1) is a ~8 kDa protein. Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in the regulation of many processes namely cell-cycle, apoptosis, autophagy and DNA repair responses. Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A. Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation. Negatively regulates apoptosis through interaction with PTMA.

1. Encinar, JA. et al. (2001) The Journal of biological chemistry 276, 2742-51. PMID: 11056169

2. Hoffmeister, A. et al. (2002) The Journal of biological chemistry 277, 22314-9. PMID: 11940591

3. Malicet, C. et al. (2006) Biochemical and biophysical research communications 339, 284-9. PMID: 16300740

4. Malicet, C. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 2671-6. PMID: 16478804

5. Clark, DW. et al. (2008) Current cancer drug targets 8, 421-30. PMID: 18690848

6. Gironella, M. et al. (2009) Journal of cellular physiology 221, 594-602. PMID: 19650074

7. Sambasivan, R. et al. (2009) Journal of cell science 122, 3481-91. PMID: 19723804

8. Kong, DK. et al. (2010) Molecular biology of the cell 21, 1335-49. PMID: 20181828

9. Hamidi, T. et al. (2012) The Journal of clinical investigation 122, 2092-103. PMID: 22565310

10. Vincent, AJ. et al. (2012) FEBS letters 586, 3429-34. PMID: 22858377

Note

For research use only

Images

References

Datasheet

Anti-Human NUPR1 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Assay Kits

Anti-Human NUPR1 Polyclonal Antibody (HA758014)

Overview

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References

Datasheet

SDS

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