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Anti-Human P2RX6 Polyclonal Antibody (HT117014)

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Overview
Catalog No.HT117014
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human P2RX6 (Lys61-Gly333).
Target Purinergic receptor, P2XM, Purinergic receptor P2X-like 1, P2RXL1, P2X purinoceptor 6, P2X6, ATP receptor, P2RX6
Purification Purified by antigen affinity column.
Accession O15547
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

P2X purinoceptor 6 (P2RX6) is a ~48 kDa protein. May act as a modulatory subunit rather than a functional channel. Unlike other P2XRs members, P2RX6 does not seem to form functional homotrimers. P2RX6 requires the presence of P2RX4 or P2RX2 to shuttle it to the plasma membrane where it may form functional heterotrimeric receptors at the plasma membrane. P2RX6 can be translocated to the nucleus and functions as a nuclear regulator of post-transcriptional modifications in neurons.

1. Hausmann, R. et al. (2012) The Journal of biological chemistry 287, 13930-43. PMID: 22378790
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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V₁ (Stock Vol.)
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C₂ (Working Conc.)
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Anti-Human P2RX6 Polyclonal Antibody

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