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Anti-Human PAN2 Polyclonal Antibody (HD552014)

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Overview
Catalog No.HD552014
Description
Anti-Human PAN2 Polyclonal Antibody (HD552014) is a rabbit polyclonal antibody detecting PAN2. Suitable for Mouse, Human, and Rat.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human PAN2 (Gly60-Ser360).
Target EC:3.1.13.4, Inactive ubiquitin carboxyl-terminal hydrolase 52, KIAA0710, PAB1P-dependent poly(A)-specific ribonuclease, PAN deadenylation complex subunit 2, PAN2, PAN2-PAN3 deadenylation complex catalytic subunit PAN2, Poly(A)-nuclease deadenylation complex subunit 2, USP52
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q504Q3
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

PAN2-PAN3 deadenylation complex catalytic subunit PAN2 is a ~135 kDa protein. Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response.

Note For research use only
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Anti-Human PAN2 Polyclonal Antibody

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