Anti-Human Perforin Recombinant Antibody (SAA0104), APC (HB886137)

Name: Anti-Human Perforin Recombinant Antibody (SAA0104), APC
Brand: abinScience
SKU: HB886137
Price: 290 USD
Availability: InStock

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Overview

Catalog No.	HB886137
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	SAA0104
Conjugation	APC
Clonality	Monoclonal
Target	Cytolysin, Perforin-1, Lymphocyte pore-forming protein, PFP, PRF1, P1
Endotoxin level	Please contact with the lab for this information.
Accession	P14222
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	Perforin-1 is a ~61 kDa protein. Pore-forming protein that plays a key role in granzyme-mediated programmed cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by mediating the passage and uptake of cytotoxic granzymes. 1. Praper, T. et al. (2011) The Journal of biological chemistry 286, 2946-55. PMID: 20889983 2. Law, RH. et al. (2010) Nature 468, 447-51. PMID: 21037563 3. Stewart, SE. et al. (2014) The Journal of biological chemistry 289, 9172-81. PMID: 24558045 4. Vergelli, M. et al. (1997) Journal of immunology (Baltimore, Md. : 1950) 158, 2756-61. PMID: 9058810 5. Ando, K. et al. (1997) Journal of immunology (Baltimore, Md. : 1950) 158, 5283-91. PMID: 9164947 6. Thiery, J. et al. (2010) Blood 115, 1582-93. PMID: 20038786 7. Czystowska, M. et al. (2010) Journal of molecular medicine (Berlin, Germany) 88, 577-88. PMID: 20225066 8. Zhou, Z. et al. (2020) Science (New York, N.Y.) 368. PMID: 32299851
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human Perforin Recombinant Antibody (SAA0104), APC.pdf

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Anti-Human Perforin Recombinant Antibody (SAA0104), APC (HB886137)

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