| Target |
PIP5K1-alpha, PtdIns(4)P-5-kinase 1 alpha, Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha, PIP5KIalpha, 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha, PIP5K1A, Phosphatidylinositol 4-phosphate 5-kinase type I alpha |
| Background | Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A) is a ~62 kDa protein. Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility. PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3). PIP5K1A-mediated phosphorylation of PtdIns(4)P is the predominant pathway for PtdIns(4,5)P2 synthesis. Can also use phosphatidylinositol (PtdIns) as substrate in vitro. Together with PIP5K1C, is required for phagocytosis, both enzymes regulating different types of actin remodeling at sequential steps. 1. Shulga, YV. et al. (2011) Journal of molecular biology 409, 101-12. PMID: 214775962. Shulga, YV. et al. (2012) The Journal of biological chemistry 287, 35953-63. PMID: 229422763. Loijens, JC. et al. (1996) The Journal of biological chemistry 271, 32937-43. PMID: 89551364. Xie, Z. et al. (2009) Molecular biology of the cell 20, 1695-704. PMID: 191583935. Chao, WT. et al. (2010) The Journal of cell biology 190, 247-62. PMID: 20660631 |
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