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Anti-Human PIWIL1 Polyclonal Antibody (HD665014)

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Overview
Catalog No.HD665014
Description
Anti-Human PIWIL1 Polyclonal Antibody (HD665014) is a rabbit polyclonal antibody detecting PIWIL1. Suitable for Mouse and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human PIWIL1 (Lys461-Leu861).
Target EC:3.1.26.-, HIWI, PIWIL1, Piwi-like protein 1
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q96J94
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Piwi-like protein 1 (PIWIL1) is a ~98 kDa protein. Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Strongly prefers a uridine in the first position of their guide (g1U preference, also named 1U-bias). Not involved in the piRNA amplification loop, also named ping-pong amplification cycle.

Note For research use only
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Formula
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Anti-Human PIWIL1 Polyclonal Antibody

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