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Anti-Human PNPT1 Polyclonal Antibody (HC241014)

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Overview
Catalog No.HC241014
Description
Anti-Human PNPT1 Polyclonal Antibody (HC241014) is a rabbit polyclonal antibody detecting PNPT1. Suitable for Mouse and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human PNPT1 (Gly43-Lys595).
Target 3'-5' RNA exonuclease OLD35, EC:2.7.7.8, PNPASE, PNPT1, PNPase 1, PNPase old-35, Polynucleotide phosphorylase 1, Polynucleotide phosphorylase-like protein, Polyribonucleotide nucleotidyltransferase 1, mitochondrial
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q8TCS8
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Polyribonucleotide nucleotidyltransferase 1, mitochondrial (PNPT1) is a ~85 kDa protein. RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules.

1. Pietras, Z. et al. (2018) Nature communications 9, 2558. PMID: 29967381
2. Kim, S. et al. (2024) Molecular cell 84, 2935-2948.e7. PMID: 39019044
Note For research use only
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Formula
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Anti-Human PNPT1 Polyclonal Antibody

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