Anti-Human PPP1CC Polyclonal Antibody (HW554014)

Name: Anti-Human PPP1CC Polyclonal Antibody
Brand: abinScience
SKU: HW554014
Price: 96 USD
Availability: InStock

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References
Datasheet
SDS

Overview

Catalog No.

HW554014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human PPP1CC (Met1-Lys323).

Target

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit, PP-1G, Protein phosphatase 1C catalytic subunit, PPP1CC

Purification

Purified by antigen affinity column.

Accession

P36873

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PPP1CC) is a ~36 kDa protein. Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II.

1. Djouder, N. et al. (2007) Molecular cell 28, 28-40. PMID: 17936702

2. Takagi, M. et al. (2014) The Journal of biological chemistry 289, 22877-22887. PMID: 25012651

3. Lee, JH. et al. (2010) The Journal of biological chemistry 285, 24466-76. PMID: 20516061

4. Schmutz, I. et al. (2011) PloS one 6, e21325. PMID: 21712997

5. Sivakumar, S. et al. (2017) Biology open 6, 1672-1679. PMID: 28982702

6. Nie, H. et al. (2013) Nature medicine 19, 322-8. PMID: 23396208

7. Wies, E. et al. (2013) Immunity 38, 437-49. PMID: 23499489

8. Liau, NPD. et al. (2022) Nature 609, 400-407. PMID: 35768504

9. Kwon, JJ. et al. (2022) Nature 609, 408-415. PMID: 35831509

Note

For research use only.

Images

Western blot

Lane 1: Mouse brain lysate
Lane 2: Rat brain lysate

References

Datasheet

Anti-Human PPP1CC Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human PPP1CC Polyclonal Antibody (HW554014)

Overview

Images

References

Datasheet

SDS

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