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Anti-Human PPP1R15A Polyclonal Antibody (HF783014)

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Overview
Catalog No.HF783014
Description
Anti-Human PPP1R15A Polyclonal Antibody (HF783014) is a rabbit polyclonal antibody detecting PPP1R15A in ELISA, IHC, WB. Suitable for Human and Bovine.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human PPP1R15A (Ala571-Asn621).
Target GADD34, Protein phosphatase 1 regulatory subunit 15A, PPP1R15A, Growth arrest and DNA damage-inducible protein GADD34, Myeloid differentiation primary response protein MyD116 homolog
Purification Purified by antigen affinity column.
Accession O75807
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) is a ~73 kDa protein. Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing p53/TP53 phosphorylation on 'Ser-15'. Plays an essential role in autophagy by tuning translation during starvation, thus enabling lysosomal biogenesis and a sustained autophagic flux. Also acts a viral restriction factor by attenuating HIV-1 replication.

1. Choy, MS. et al. (2015) Cell reports 11, 1885-91. PMID: 26095357
2. Santos, CX. et al. (2016) The EMBO journal 35, 319-34. PMID: 26742780
3. Shi, W. et al. (2004) The Journal of cell biology 164, 291-300. PMID: 14718519
4. Yagi, A. et al. (2003) Journal of cellular biochemistry 90, 1242-9. PMID: 14635196
5. Gambardella, G. et al. (2020) Science advances 6. PMID: 32978159
6. Ishaq, M. et al. (2020) Virology 540, 119-131. PMID: 31778897
Note For research use only.
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Datasheet
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Formula
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Anti-Human PPP1R15A Polyclonal Antibody

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