Anti-Human PPP6C Polyclonal Antibody (HT366014)

Name: Anti-Human PPP6C Polyclonal Antibody
Brand: abinScience
SKU: HT366014
Price: 168 USD
Availability: InStock

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Overview
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Datasheet
SDS

Overview

Catalog No.

HT366014

Description

Anti-Human PPP6C Polyclonal Antibody (HT366014) is a rabbit polyclonal antibody detecting PPP6C in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human PPP6C (Met1-Leu305).

Target

Serine/threonine-protein phosphatase 6 catalytic subunit, PP6C, 3.1.3.16, Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed, PPP6C, PPP6

Purification

Purified by antigen affinity column.

Accession

O00743

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Serine/threonine-protein phosphatase 6 catalytic subunit (PPP6C) is a ~35 kDa protein. Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, regulates spindle positioning. Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7.

1. Kajino, T. et al. (2006) The Journal of biological chemistry 281, 39891-6. PMID: 17079228

2. Tan, P. et al. (2017) Molecular cell 68, 293-307.e5. PMID: 29053956

3. Li, M. et al. (2020) Protein & cell 11, 584-599. PMID: 32474700

4. Filali, M. et al. (1999) Journal of cellular biochemistry 73, 153-63. PMID: 10227379

5. Stefansson, B. et al. (2007) Cell cycle (Georgetown, Tex.) 6, 1386-92. PMID: 17568194

6. Kotak, S. et al. (2016) Journal of cell science 129, 3015-25. PMID: 27335426

7. Ni, G. et al. (2020) mBio 11. PMID: 32753499

Note

For research use only.

Images

References

Datasheet

Anti-Human PPP6C Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human PPP6C Polyclonal Antibody (HT366014)

Overview

Images

References

Datasheet

SDS

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