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Anti-Human PRKACA Polyclonal Antibody (HB890014)

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Overview
Catalog No.HB890014
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human PRKACA (His40-Lys310).
Target PRKACA, PKACA, PKA C-alpha, cAMP-dependent protein kinase catalytic subunit alpha
Purification Purified by antigen affinity column.
Accession P17612
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) is a ~40 kDa protein. Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, histone H1.4 (H1-4), PSMC5/RPT6, PJA2, RYR2, RORA, SOX9, UHRF1 and VASP. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts.

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2. D'Souza, T. et al. (2005) The Journal of biological chemistry 280, 26233-40. PMID: 15905176
3. Pasqualucci, L. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 395-400. PMID: 16387847
4. Xu, H. et al. (2008) Breast cancer research and treatment 107, 63-70. PMID: 17333334
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7. Shirakawa, K. et al. (2008) Nature structural & molecular biology 15, 1184-91. PMID: 18836454
8. Wang, W. et al. (2010) Molecular and cellular biochemistry 338, 115-22. PMID: 19949837
9. Gambaryan, S. et al. (2010) The Journal of biological chemistry 285, 18352-63. PMID: 20356841
10. Murshid, A. et al. (2010) PloS one 5, e13830. PMID: 21085490
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human PRKACA Polyclonal Antibody

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