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Anti-Human PRMT6 Polyclonal Antibody (HP638014)

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Overview
Catalog No.HP638014
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human PRMT6 (Arg82-Asp375).
Target Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6, Histone-arginine N-methyltransferase PRMT6, Protein arginine N-methyltransferase 6, PRMT6, HRMT1L6
Purification Purified by antigen affinity column.
Accession Q96LA8
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Protein arginine N-methyltransferase 6 (PRMT6) is a ~41 kDa protein. Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53.

1. Guccione, E. et al. (2007) Nature 449, 933-7. PMID: 17898714
2. Iberg, AN. et al. (2008) The Journal of biological chemistry 283, 3006-3010. PMID: 18077460
3. Hyllus, D. et al. (2007) Genes & development 21, 3369-80. PMID: 18079182
4. Lakowski, TM. et al. (2009) The Biochemical journal 421, 253-61. PMID: 19405910
5. Yan, WW. et al. (2018) EMBO reports 19. PMID: 30420520
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Human PRMT6 Polyclonal Antibody

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