Anti-Human PSEN1/Presenilin-1 Recombinant Antibody (SAA1782) (HW641013)

Name: Anti-Human PSEN1/Presenilin-1 Recombinant Antibody (SAA1782)
Brand: abinScience
SKU: HW641013
Price: 196 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HW641013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1782

Clonality

Monoclonal

Target

PSEN1, AD3, Presenilin-1, Protein S182, PS-1, PSNL1, PS1-CTF12, PS1

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P49768

RRID

Anti-Human PSEN1/Presenilin-1 Antibody (SAA1782) (abinScience Cat# HW641013, RRID:AB_3727544)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Presenilin-1 (PSEN1) is a ~52 kDa protein. Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CDH1; this stabilizes the complexes between CDH1 (E-cadherin) and its interaction partners CTNNB1 (beta-catenin), CTNND1 and JUP (gamma-catenin). Under conditions of apoptosis or calcium influx, cleaves CDH1.

1. Wolfe, MS. et al. (1999) Nature 398, 513-7. PMID: 10206644

2. Steiner, H. et al. (1999) Biochemistry 38, 14600-5. PMID: 10545183

3. Ray, WJ. et al. (1999) The Journal of biological chemistry 274, 36801-7. PMID: 10593990

4. Kulic, L. et al. (2000) Proceedings of the National Academy of Sciences of the United States of America 97, 5913-8. PMID: 10811883

5. Berezovska, O. et al. (2000) Journal of neurochemistry 75, 583-93. PMID: 10899933

6. Edbauer, D. et al. (2003) Nature cell biology 5, 486-8. PMID: 12679784

7. Kimberly, WT. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 6382-7. PMID: 12740439

8. Fraering, PC. et al. (2004) Biochemistry 43, 9774-89. PMID: 15274632

9. Heilig, EA. et al. (2010) The Journal of biological chemistry 285, 22350-9. PMID: 20460383

10. Lu, P. et al. (2014) Nature 512, 166-170. PMID: 25043039

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human PSEN1/Presenilin-1 Antibody (SAA1782)

References

Datasheet

Anti-Human PSEN1/Presenilin-1 Recombinant Antibody (SAA1782).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human PSEN1/Presenilin-1 Recombinant Antibody (SAA1782) (HW641013)

Overview

Images

References

Datasheet

SDS

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