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Anti-Human PTGR1 Polyclonal Antibody (HD224014)

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Overview
Catalog No.HD224014
Description
Anti-Human PTGR1 Polyclonal Antibody (HD224014) is a rabbit polyclonal antibody detecting PTGR1. Suitable for Human.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human PTGR1 (Met1-Ala329).
Target 15-oxoprostaglandin 13-reductase, D3T-inducible gene 1 protein, DIG-1, Dithiolethione-inducible gene 1 protein, EC:1.3.1.48, EC:1.3.1.74, LTB4DH, Leukotriene B4 12-hydroxydehydrogenase, NAD(P)H-dependent alkenal/one oxidoreductase, PRG-1, PTGR1, Prostaglandin reductase 1
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q14914
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Prostaglandin reductase 1 (PTGR1) is a ~35 kDa protein. NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha. Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites. Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site. May play a role in metabolic detoxification of alkenals and ketones.

1. Mesa, J. et al. (2015) Chemico-biological interactions 234, 105-13. PMID: 25619643
Note For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
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C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Human PTGR1 Polyclonal Antibody

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