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Anti-Human PTPN22 Polyclonal Antibody (HB930014)

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Overview
Catalog No.HB930014
Description
Anti-Human PTPN22 Polyclonal Antibody (HB930014) is a rabbit polyclonal antibody detecting PTPN22 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human PTPN22 (Met1-Gly303).
Target PTPN8, Lymphoid phosphatase, PTPN22, PEST-domain phosphatase, LyP, Tyrosine-protein phosphatase non-receptor type 22, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, PEP
Purification Purified by antigen affinity column.
Accession Q9Y2R2
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Tyrosine-protein phosphatase non-receptor type 22 (PTPN22) is a ~91 kDa protein. Acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2.

1. Wu, J. et al. (2006) The Journal of biological chemistry 281, 11002-10. PMID: 16461343
2. Yu, X. et al. (2007) Proceedings of the National Academy of Sciences of the United States of America 104, 19767-72. PMID: 18056643
3. Yu, X. et al. (2011) The Journal of biological chemistry 286, 30526-30534. PMID: 21719704
4. Wang, Y. et al. (2013) Immunity 39, 111-22. PMID: 23871208
5. Spalinger, MR. et al. (2013) PloS one 8, e72384. PMID: 23991106
6. Spalinger, MR. et al. (2016) The Journal of clinical investigation 126, 1783-800. PMID: 27043286
Note For research use only.
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Formula
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Anti-Human PTPN22 Polyclonal Antibody

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