Anti-Human RAB23 Polyclonal Antibody (HP968014)

Name: Anti-Human RAB23 Polyclonal Antibody
Brand: abinScience
SKU: HP968014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HP968014

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human RAB23 (Met1-Ser186).

Target

RAB23, Ras-related protein Rab-23

Purification

Purified by antigen affinity column.

Accession

Q9ULC3

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Ras-related protein Rab-23 (RAB23) is a ~26 kDa protein. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. In conjunction with IFT57 and KIF17, it drives the localization of specific G protein-coupled receptors, such as the dopamime receptor DRD1, to primary cilia. Has a critical role in the formation and elongation of neuronal primary cilia, thereby impacting the activation of sonic hedgehog (Shh) signaling. Additionally, it is involved in the down-regulation of Shh signaling by cooperating with SUFU to prevent the nuclear import of GLI1 transcription factor, thus suppressing its transcriptional activity.

1. Leaf, A. et al. (2015) eLife 4. PMID: 26182404

2. Leong, WY. et al. (2025) PLoS genetics 21, e1011611. PMID: 40825043

3. Chi, S. et al. (2012) Cellular signalling 24, 1222-8. PMID: 22365972

4. Chau, YY. et al. (2025) The Journal of biological chemistry 301, 108036. PMID: 39615683

5. Nozawa, T. et al. (2012) Cellular microbiology 14, 1149-65. PMID: 22452336

Note

For research use only.

Images

References

Datasheet

Anti-Human RAB23 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human RAB23 Polyclonal Antibody (HP968014)

Overview

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References

Datasheet

SDS

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