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Anti-Human RABEP1 Polyclonal Antibody (HS824014)

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Overview
Catalog No.HS824014
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human RABEP1 (Ser464-Glu552).
Target RABPT5, RABEP1, Rabaptin-4, RABPT5A, Rab GTPase-binding effector protein 1, Renal carcinoma antigen NY-REN-17, RAB5EP, Rabaptin-5alpha, Rabaptin-5
Purification Purified by antigen affinity column.
Accession Q15276
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Rab GTPase-binding effector protein 1 (RABEP1) is a ~99 kDa protein. Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Forms a complex with RABGEF1 that stimulates RABGEF1-mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium.

1. Ninkovic, M. et al. (2012) FEBS letters 586, 3077-84. PMID: 22841712
2. Horiuchi, H. et al. (1997) Cell 90, 1149-59. PMID: 9323142
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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