

| Catalog No. | HY382014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-Human RALB Polyclonal Antibody (HY382014) is a rabbit polyclonal antibody detecting RALB in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Species reactivity | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Clonality | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogen | E. coli - derived recombinant Human RALB (Ser11-Leu206). | ||||||||
| Target | Ras-related protein Ral-B, RALB | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | P11234 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Ras-related protein Ral-B (RALB) is a ~23 kDa protein. Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Required for suppression of apoptosis. 1. Nakashima, S. et al. (1999) The EMBO journal 18, 3629-42. PMID: 10393179 2. Falsetti, SC. et al. (2007) Molecular and cellular biology 27, 8003-14. PMID: 17875936 3. Cascone, I. et al. (2008) The EMBO journal 27, 2375-87. PMID: 18756269 | ||||||||
| Note | For research use only. |

Western blot analysis was performed using anti-RALB polyclonal antibody at 1ug/mL on various samples.
Lane 1: MCF-7 cell lysate
Lane 2: Mouse brain lysate
Lane 3: Mouse lung lysate
Lane 4: Rat brain lysate
Lane 5: Rat lung lysate
Lane 6: Rat kidney lysate
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