Anti-Human RBM15B Polyclonal Antibody (HP636014)

Name: Anti-Human RBM15B Polyclonal Antibody
Brand: abinScience
SKU: HP636014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HP636014

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human RBM15B (Asn710-Ala890).

Target

HuOTT3, RBM15B, One-twenty two protein 3, OTT3, RNA-binding motif protein 15B, HsOTT3, Putative RNA-binding protein 15B

Purification

Purified by antigen affinity column.

Accession

Q8NDT2

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Putative RNA-binding protein 15B (RBM15B) is a ~97 kDa protein. RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex. Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist. Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation.

1. Hiriart, E. et al. (2005) The Journal of biological chemistry 280, 36935-45. PMID: 16129689

2. Patil, DP. et al. (2016) Nature 537, 369-373. PMID: 27602518

3. Loyer, P. et al. (2011) The Journal of biological chemistry 286, 147-59. PMID: 21044963

4. Uranishi, H. et al. (2009) The Journal of biological chemistry 284, 26106-16. PMID: 19586903

Note

For research use only.

Images

References

Datasheet

Anti-Human RBM15B Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human RBM15B Polyclonal Antibody (HP636014)

Overview

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References

Datasheet

SDS

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