

| Catalog No. | HW831014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Species reactivity | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Clonality | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogen | E. coli - derived recombinant Human RGS2 (Ser73-Lys201). | ||||||||
| Target | G0S8, Regulator of G-protein signaling 2, Cell growth-inhibiting gene 31 protein, G0/G1 switch regulatory protein 8, RGS2 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | P41220 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Regulator of G-protein signaling 2 (RGS2) is a ~24 kDa protein. Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. It is involved in the negative regulation of the angiotensin-activated signaling pathway. Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle. 1. Cunningham, ML. et al. (2001) The Journal of biological chemistry 276, 5438-44. PMID: 11063746 2. Kimple, AJ. et al. (2009) The Journal of biological chemistry 284, 19402-11. PMID: 19478087 3. Phan, HTN. et al. (2017) Molecular pharmacology 92, 451-458. PMID: 28784619 4. Nguyen, CH. et al. (2009) The Journal of cell biology 186, 755-65. PMID: 19736320 | ||||||||
| Note | For research use only. |
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