Anti-Human RXRA Polyclonal Antibody (HB113014)

Name: Anti-Human RXRA Polyclonal Antibody
Brand: abinScience
SKU: HB113014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HB113014

Description

Anti-Human RXRA Polyclonal Antibody (HB113014) is a rabbit polyclonal antibody detecting RXRA in ELISA, IHC, WB. Suitable for Mouse, Rat, Bovine, Dog, and Danio rerio.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human RXRA (Thr223-Thr462).

Target

Retinoid X receptor alpha, RXRA, Nuclear receptor subfamily 2 group B member 1, NR2B1, Retinoic acid receptor RXR-alpha

Purification

Purified by antigen affinity column.

Accession

P19793

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Retinoic acid receptor RXR-alpha (RXRA) is a ~50 kDa protein. Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription. The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression.

1. Liu, B. et al. (2000) The Journal of biological chemistry 275, 33607-13. PMID: 10874028

2. Harish, S. et al. (2000) Biochemical and biophysical research communications 279, 853-7. PMID: 11162439

3. Tsutsumi, T. et al. (2002) Hepatology (Baltimore, Md.) 35, 937-46. PMID: 11915042

4. Tsai, JM. et al. (2023) Molecular cell 83, 2753-2767.e10. PMID: 37478846

5. Gorla-Bajszczak, A. et al. (1999) Molecular and cellular endocrinology 147, 37-47. PMID: 10195690

6. Jaye, MC. et al. (2005) Journal of medicinal chemistry 48, 5419-22. PMID: 16107141

7. Zhao, WX. et al. (2007) Molecular endocrinology (Baltimore, Md.) 21, 2877-89. PMID: 17761950

8. Chao, EY. et al. (2008) Journal of medicinal chemistry 51, 5758-65. PMID: 18800767

10. Lee, DY. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 2072-2077. PMID: 28167758

Note

For research use only.

Images

References

Datasheet

Anti-Human RXRA Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-Human RXRA Polyclonal Antibody (HB113014)

Overview

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References

Datasheet

SDS

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