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Anti-Human SAR1B Polyclonal Antibody (HA923014)

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Overview
Catalog No.HA923014
Description
Anti-Human SAR1B Polyclonal Antibody (HA923014) is a rabbit polyclonal antibody detecting SAR1B in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human SAR1B (Met1-Asp198).
Target GTP-binding protein SAR1b, SAR1B, SARB, GTP-binding protein B, SARA2, GTBPB
Purification Purified by antigen affinity column.
Accession Q9Y6B6
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Small COPII coat GTPase SAR1B is a ~22 kDa protein. Small GTPase that cycles between an active GTP-bound and an inactive GDP-bound state and mainly functions in vesicle-mediated endoplasmic reticulum (ER) to Golgi transport. The active GTP-bound form inserts into the endoplasmic reticulum membrane where it recruits the remainder of the coat protein complex II/COPII. The coat protein complex II assembling and polymerizing on endoplasmic reticulum membrane is responsible for both the sorting of cargos and the deformation and budding of membranes into vesicles destined to the Golgi. In contrast to SAR1A, SAR1B specifically interacts with the cargo receptor SURF4 to mediate the transport of lipid-carrying lipoproteins including APOB and APOA1 from the endoplasmic reticulum to the Golgi and thereby, indirectly regulates lipid homeostasis. In addition to its role in vesicle trafficking, can also function as a leucine sensor regulating TORC1 signaling and more indirectly cellular metabolism, growth and survival.

1. Cutrona, MB. et al. (2013) Traffic (Copenhagen, Denmark) 14, 691-708. PMID: 23433038
2. Melville, DB. et al. (2020) The Journal of biological chemistry 295, 8401-8412. PMID: 32358066
3. Wang, X. et al. (2021) Cell metabolism 33, 350-366.e7. PMID: 33186557
4. Huang, Q. et al. (2023) Proteins 91, 518-531. PMID: 36369712
5. Chen, J. et al. (2021) Nature 596, 281-284. PMID: 34290409
Note For research use only.
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Datasheet
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Formula
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Anti-Human SAR1B Polyclonal Antibody

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