Anti-Human SCN11A Recombinant Antibody (SAA1857) (HA935013)

Name: Anti-Human SCN11A Recombinant Antibody (SAA1857)
Brand: abinScience
SKU: HA935013
Price: 196 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HA935013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1857

Clonality

Monoclonal

Target

SCN11A, hNaN, SNS2, PN5, Sodium channel protein type XI subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.9, SCN12A, Sodium channel protein type 11 subunit alpha, Sensory neuron sodium channel 2, Peripheral nerve sodium channel 5

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9UI33

RRID

Anti-Human SCN11A Antibody (SAA1857) (abinScience Cat# HA935013, RRID:AB_3727620)
_x005F_x000D_

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Sodium channel protein type 11 subunit alpha (SCN11A) is a ~204 kDa protein. Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Involved in membrane depolarization during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system. Also involved in rapid BDNF-evoked neuronal depolarization.

1. Dib-Hajj, SD. et al. (1999) FEBS letters 462, 117-20. PMID: 10580103

2. Blum, R. et al. (2002) Nature 419, 687-93. PMID: 12384689

3. Leipold, E. et al. (2013) Nature genetics 45, 1399-404. PMID: 24036948

4. Huang, J. et al. (2014) Brain : a journal of neurology 137, 1627-42. PMID: 24776970

5. Han, C. et al. (2015) Neuromolecular medicine 17, 158-69. PMID: 25791876

6. Leipold, E. et al. (2015) Nature communications 6, 10049. PMID: 26645915

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human SCN11A Antibody (SAA1857)

References

Datasheet

Anti-Human SCN11A Recombinant Antibody (SAA1857).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human SCN11A Recombinant Antibody (SAA1857) (HA935013)

Overview

Images

References

Datasheet

SDS

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