Anti-Human SCUBE2 Recombinant Antibody (SAA1911) (HA065013)

Name: Anti-Human SCUBE2 Recombinant Antibody (SAA1911)
Brand: abinScience
SKU: HA065013
Price: 196 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HA065013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1911

Clonality

Monoclonal

Target

Signal peptide, CUB and EGF-like domain-containing protein 2, SCUBE2, Protein CEGP1, Scube/You, CEGP1

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9NQ36

RRID

Anti-Human SCUBE2 Antibody (SAA1911) (abinScience Cat# HA065013, RRID:AB_3727675)
_x005F_x005F_x000D_

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Signal peptide, CUB and EGF-like domain-containing protein 2 (SCUBE2) is a ~109 kDa protein. Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to increase SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis.

1. Creanga, A. et al. (2012) Genes & development 26, 1312-25. PMID: 22677548

2. Tukachinsky, H. et al. (2012) Cell reports 2, 308-20. PMID: 22902404

3. Jakobs, P. et al. (2014) Journal of cell science 127, 1726-37. PMID: 24522195

4. Lin, YC. et al. (2017) Arteriosclerosis, thrombosis, and vascular biology 37, 144-155. PMID: 27834687

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human SCUBE2 Antibody (SAA1911)

References

Datasheet

Anti-Human SCUBE2 Recombinant Antibody (SAA1911).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human SCUBE2 Recombinant Antibody (SAA1911) (HA065013)

Overview

Images

References

Datasheet

SDS

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