Anti-Human SENP3 Polyclonal Antibody (HP948014)

Name: Anti-Human SENP3 Polyclonal Antibody
Brand: abinScience
SKU: HP948014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HP948014

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human SENP3 (Glu311-Val574).

Target

Sentrin-specific protease 3, Sentrin/SUMO-specific protease SENP3, SENP3, SUSP3, SUMO-1-specific protease 3, SSP3

Purification

Purified by antigen affinity column.

Accession

Q9H4L4

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Sentrin-specific protease 3 (SENP3) is a ~65 kDa protein. Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1.

1. Gong, L. et al. (2006) The Journal of biological chemistry 281, 15869-77. PMID: 16608850

2. Gao, SS. et al. (2020) Science advances 6, eaba7822. PMID: 32832608

3. Zhang, T. et al. (2022) Nature communications 13, 5133. PMID: 36050397

4. Grégoire, S. et al. (2005) Molecular and cellular biology 25, 2273-87. PMID: 15743823

5. Klein, UR. et al. (2009) Molecular biology of the cell 20, 410-8. PMID: 18946085

6. Huang, C. et al. (2009) The EMBO journal 28, 2748-62. PMID: 19680224

7. Yun, C. et al. (2008) The Journal of cell biology 183, 589-95. PMID: 19015314

8. Haindl, M. et al. (2008) EMBO reports 9, 273-9. PMID: 18259216

9. Fanis, P. et al. (2012) Molecular & cellular proteomics : MCP 11, 1263-73. PMID: 22872859

Note

For research use only.

Images

References

Datasheet

Anti-Human SENP3 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human SENP3 Polyclonal Antibody (HP948014)

Overview

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Datasheet

SDS

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