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Anti-Human SGPL1 Polyclonal Antibody (HF762014)

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Overview
Catalog No.HF762014
Description
Anti-Human SGPL1 Polyclonal Antibody (HF762014) is a rabbit polyclonal antibody detecting SGPL1. Suitable for Human.
Species reactivityHuman
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human SGPL1 (Ser122-Tyr550).
Target EC:4.1.2.27, KIAA1252, S1PL, SGPL1, SP-lyase 1, SPL 1, Sphingosine-1-phosphate aldolase, Sphingosine-1-phosphate lyase 1, hSPL
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession O95470
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Sphingosine-1-phosphate lyase 1 (SGPL1) is a ~63 kDa protein. Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP.

1. Van Veldhoven, PP. et al. (2000) Biochimica et biophysica acta 1487, 128-34. PMID: 11018465
2. Reiss, U. et al. (2004) The Journal of biological chemistry 279, 1281-90. PMID: 14570870
3. Weiler, S. et al. (2014) Journal of medicinal chemistry 57, 5074-84. PMID: 24809814
4. Lovric, S. et al. (2017) The Journal of clinical investigation 127, 912-928. PMID: 28165339
Note For research use only
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Formula
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Anti-Human SGPL1 Polyclonal Antibody

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