Anti-Human SHOC2 Polyclonal Antibody (HP134014)

Name: Anti-Human SHOC2 Polyclonal Antibody
Brand: abinScience
SKU: HP134014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HP134014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SHOC2 (Ser86-Val582).

Target

Leucine-rich repeat protein SHOC-2, KIAA0862, Protein sur-8 homolog, Protein soc-2 homolog, SHOC2

Purification

Purified by antigen affinity column.

Accession

Q9UQ13

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Leucine-rich repeat protein SHOC-2 (SHOC2) is a ~64 kDa protein. Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway. Acts as a scaffolding protein in the SMP complex. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities. The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c.

1. Li, W. et al. (2000) Genes & development 14, 895-900. PMID: 10783161

2. Rodriguez-Viciana, P. et al. (2006) Molecular cell 22, 217-30. PMID: 16630891

3. Hannig, V. et al. (2014) Human mutation 35, 1290-4. PMID: 25137548

4. Liau, NPD. et al. (2022) Nature 609, 400-407. PMID: 35768504

5. Hauseman, ZJ. et al. (2022) Nature 609, 416-423. PMID: 35830882

6. Kwon, JJ. et al. (2022) Nature 609, 408-415. PMID: 35831509

7. Bonsor, DA. et al. (2022) Nature structural & molecular biology 29, 966-977. PMID: 36175670

Note

For research use only.

Images

References

Datasheet

Anti-Human SHOC2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-Human SHOC2 Polyclonal Antibody (HP134014)

Overview

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References

Datasheet

SDS

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