Anti-Human SLC22A6 Polyclonal Antibody (HS924014)

Name: Anti-Human SLC22A6 Polyclonal Antibody
Brand: abinScience
SKU: HS924014
Price: 168 USD
Availability: InStock

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References
Datasheet
SDS

Overview

Catalog No.

HS924014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SLC22A6 (Thr41-Arg131).

Target

hROAT1, PAH transporter, Solute carrier family 22 member 6, PAHT, Renal organic anion transporter 1, hPAHT, OAT1, SLC22A6, Organic anion transporter 1, hOAT1

Purification

Purified by antigen affinity column.

Accession

Q4U2R8

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Solute carrier family 22 member 6 (SLC22A6) is a ~61 kDa protein. Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as 2-oxoglutarate or glutarate. Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine. Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins. Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion. Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP.

1. Jung, KY. et al. (2001) Life sciences 69, 2123-35. PMID: 11669456

2. Kimura, H. et al. (2002) The Journal of pharmacology and experimental therapeutics 301, 293-8. PMID: 11907186

3. Deguchi, T. et al. (2004) Kidney international 65, 162-74. PMID: 14675047

4. Uwai, Y. et al. (2012) Pharmacological research 65, 254-60. PMID: 22108572

5. Uwai, Y. et al. (2013) Bioscience, biotechnology, and biochemistry 77, 1517-21. PMID: 23832370

6. Ohashi, A. et al. (2017) Molecular and cellular biochemistry 435, 97-108. PMID: 28534121

7. Lu, R. et al. (1999) The American journal of physiology 276, F295-303. PMID: 9950961

8. Hosoyamada, M. et al. (1999) The American journal of physiology 276, F122-8. PMID: 9887087

Note

For research use only.

Images

References

Datasheet

Anti-Human SLC22A6 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human SLC22A6 Polyclonal Antibody (HS924014)

Overview

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References

Datasheet

SDS

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