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Anti-Human SLC25A46 Polyclonal Antibody (HP731014)

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Overview
Catalog No.HP731014
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human SLC25A46 (Glu335-Gly381).
Target TB1, Solute carrier family 25 member 46, SLC25A46
Purification Purified by antigen affinity column.
Accession Q96AG3
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Mitochondrial outer membrane protein SLC25A46 is a ~46 kDa protein. Transmembrane protein of the mitochondrial outer membrane that controls mitochondrial organization. May regulate the assembly of the MICOS (mitochondrial contact site and cristae organizing system) complex which is essential to the biogenesis and dynamics of mitochondrial cristae, the inwards folds of the inner mitochondrial membrane. Through its interaction with the EMC (endoplasmic reticulum membrane protein complex), could regulate mitochondrial lipid homeostasis and thereby mitochondrial fission.

1. Abrams, AJ. et al. (2015) Nature genetics 47, 926-32. PMID: 26168012
2. Janer, A. et al. (2016) EMBO molecular medicine 8, 1019-38. PMID: 27390132
3. Wan, J. et al. (2016) Brain : a journal of neurology 139, 2877-2890. PMID: 27543974
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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C₂ (Working Conc.)
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Anti-Human SLC25A46 Polyclonal Antibody

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