

| Catalog No. | HP576014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Species reactivity | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Host species | Rabbit | ||||||||
| Isotype | IgG | ||||||||
| Clonality | Polyclonal | ||||||||
| Immunogen | E. coli - derived recombinant Human SLC30A6 (Ser247-Asp334). | ||||||||
| Target | ZnT-6, Solute carrier family 30 member 6, Zinc transporter 6, ZNT6, SLC30A6 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Accession | Q6NXT4 | ||||||||
| Form | Liquid | ||||||||
| Storage buffer | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
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| Product Usage Information |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Background | Zinc transporter 6 (SLC30A6) is a ~51 kDa protein. Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway. As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis. 1. Suzuki, T. et al. (2005) The Journal of biological chemistry 280, 30956-62. PMID: 15994300 2. Ohana, E. et al. (2009) The Journal of biological chemistry 284, 17677-86. PMID: 19366695 3. Fukunaka, A. et al. (2009) The Journal of biological chemistry 284, 30798-806. PMID: 19759014 4. Wagatsuma, T. et al. (2022) The Journal of biological chemistry 298, 102011. PMID: 35525268 | ||||||||
| Note | For research use only. |
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